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Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats
Author(s) -
Sakhri Fatma Z.,
Adachi Naoki,
Zerizer Sakina,
Ohashi Yusuke,
Ikemoto Hideshi,
Tsukada Mana,
Kabouche Zahia,
Hisamitsu Tadashi,
Sunagawa Masataka
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6953
Subject(s) - neurogenesis , behavioural despair test , dentate gyrus , open field , corticosterone , hippocampus , hippocampal formation , endocrinology , chronic stress , medicine , elevated plus maze , anxiety , psychology , neuroscience , psychiatry , hormone , antidepressant
It is known that chronic stress is a contributing factor to several physical and mental diseases. In this study, we examined the effect of hydroethanolic extract of Cydonia oblonga fruit (HECO, 300 mg/kg) in chronically immobilized rats on physiological and behavioral parameters by the open field test (OFT), sucrose preference test (SPT), and forced swimming test (FST) and on neurological alterations by analysis of the hippocampal neurogenesis. A daily 6 hr exposure to chronic immobilization stress (CIS) for 21 consecutive days induced anxiety‐ and depressive‐like behaviors in rats' concomitant with decreased weight gain and increased plasma corticosterone (CORT) levels, rats also showed atrophy in the CA3 subregion of the hippocampus and a decreased number of Ki67 and DCX positive cells in the dentate gyrus (DG). Treatment with HECO successfully suppressed the physiological and behavioral markers of the CIS and prevents the structural abnormality and the impaired cell proliferation in the hippocampus. Moreover, the daily administration of HECO improved the mood function in normal rats. Taking together, our findings demonstrate, for the first time, the anti‐depressive effect of C. oblonga fruit by enhancing the hippocampal neurogenesis in the rat model of depression.