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Effects of Nigella sativa oil and thymoquinone against bisphenol A‐induced metabolic disorder in rats
Author(s) -
Fadishei Masoumeh,
Ghasemzadeh Rahbardar Mahboobeh,
Imenshahidi Mohsen,
Mohajeri Ahmad,
Razavi Bibi Marjan,
Hosseinzadeh Hossein
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6944
Subject(s) - thymoquinone , endocrinology , leptin , medicine , protein kinase b , adiponectin , chemistry , insulin , adipokine , pharmacology , insulin resistance , biochemistry , antioxidant , apoptosis , obesity
The underlying mechanisms of bisphenol A (BPA)‐induced metabolic disorder and the protective impact of Nigella sativa oil (NSO) and thymoquinone (TQ) against BPA‐induced metabolic disorder were investigated. Rats were treated as follows: Control, BPA (10 mg/kg), TQ (2 mg/kg), NSO (84 μL/kg), BPA + TQ (0.5, 1, 2 mg/kg), and BPA + NSO (21, 42, 84 μL/kg). BPA was administered by gavage, while, TQ and NSO were injected intraperitoneally (daily, 54 days). The weight, blood pressure, serum parameters [glucose, lipid profile, hepatic enzymes, insulin, interlukin‐6 (IL‐6), tumor necrosis factor‐alpha (TNF‐α), leptin, adiponectin], malondialdehyde (MDA), glutathione (GSH) and insulin signaling pathways [insulin receptor substrate (p‐IRS,IRS); kinase (p‐Akt,Akt); glycogen synthase kinase (p‐GS3K,GS3K)] were measured. BPA increased the blood pressure, MDA, lipid profile, hepatic enzymes, insulin, IL‐6, TNF‐α, and leptin, and decreased the GSH and phosphorylated forms of IRS, Akt, GS3K but did not alter weight, glucose, IRS, AKT, and GS3K in the liver. Administration of NSO or TQ with BPA reduced the blood pressure, liver level of MDA, lipid profile, hepatic enzymes, insulin, IL‐6, TNF‐α, leptin, and increased the liver level of GSH and p‐IRS, p‐AKT, p‐GS3K. TQ and NSO are thought to be effective in controlling metabolic disorders induced by BPA.