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Roles of plant‐derived bioactive compounds and related microRNAs in cancer therapy
Author(s) -
Zou Heng,
Li Yanli,
Liu Xiaomin,
Wu Zong,
Li Jingjing,
Ma Zhongliang
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6883
Subject(s) - microrna , metastasis , translation (biology) , berberine , cancer , biology , pharmacology , cancer research , chemistry , messenger rna , biochemistry , gene , genetics
Plant‐derived bioactive compounds, often called phytochemicals, are active substances extracted from different plants. These bioactive compounds can release therapeutic potential abilities via reducing antitumor drugs side effects or directly killing cancer cells, and others also can adjust cancer initiation and progression via regulating microRNAs (miRNAs) expression, and miRNA can regulate protein‐coding expression by restraining translation or degrading target mRNA. A mass of research showed that plant‐derived bioactive compounds including tanshinones, astragaloside IV, berberine, ginsenosides and matrine can inhibit tumor growth and metastasis by rescuing aberrant miRNAs expression, which has influence on tumor progression, microenvironment and drug resistance in multifarious cancers. This review aims to provide a novel understanding of plant‐derived bioactive compounds targeting miRNAs and shed light on their future clinical applications.