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The role of medicinal products in the treatment of inflammatory bowel diseases ( IBD ) through inhibition of TLR4 / NF‐kappaB pathway
Author(s) -
Dejban Pegah,
Nikravangolsefid Nasrin,
Chamanara Mohsen,
Dehpour Ahmadreza,
Rashidian Amir
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6866
Subject(s) - tlr4 , inflammatory bowel disease , medicine , pathogenesis , immune system , signal transduction , pharmacology , immunology , disease , biology , biochemistry
Inflammatory bowel disease (IBD) is a lifelong and recurrent disease of the gastrointestinal tract that afflicts many people in the world. Growing evidence has currently indicated that dysfunction of immune system, particularly toll‐like receptors 4 (TLR4) signaling pathway dysfunction plays a pivotal part in the pathogenesis of IBD. TLR4 signaling is involved both in the pathogenesis and in the efficacy of treatment of IBD. There are some medicinal products and herbal medicines, which their role in the treatment of IBD through modulation of TLR4 signaling has been implicated. The purpose of this review article is to summarize those medicinal products and herbal medicines.