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A systematic review of preclinical studies on the efficacy of propolis for the treatment of inflammatory bowel disease
Author(s) -
Soleimani Davood,
Miryan Mahsa,
Tutunchi Helda,
Navashenaq Jamshid G.,
Sadeghi Ehsan,
GhayourMobarhan Majid,
Ferns Gordon A.,
Ostadrahimi Alireza
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6856
Subject(s) - propolis , inflammatory bowel disease , medicine , cochrane library , colitis , ulcerative colitis , disease , gut flora , mechanism (biology) , immune system , bioinformatics , immunology , traditional medicine , randomized controlled trial , biology , philosophy , epistemology
Propolis is a resinous substance produced by bees from plants. There has been some evidence indicating that propolis may be a candidate for the treatment of inflammatory bowel disease (IBD) because of its potent antioxidant properties and ability to modulate immune response and gut microbiome. The objective of this systematic review was to investigate the role of propolis in the treatment of IBD, emphasizing possible mechanisms underlying the anti‐inflammatory properties of it. Searches were performed in ISI, PubMed/Medline, Scopus, EMBASE, and Cochrane Library databases up to March 2020. According to the studies examined in this review, the administration of propolis can be useful in attenuating many aspects of clinical, macroscopic, and histological features of colitis in animal models. The efficacy of propolis in the treatment of IBD might be attributed to its potent antioxidants and anti‐inflammatory activities. Propolis may also be involved in the modulation of the gut microbiota and in the improvement of the intestinal mucosal barrier function. The major mechanism of action is most likely to be mediated via the prevention of some transcriptional factors and associated proteins. However, future studies are warranted to investigate the clinical utility of propolis as a candidate in the treatment of IBD.