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Citrinin against breast cancer: A cytogenotoxicological study
Author(s) -
Oliveira Filho José Williams Gomes,
Andrade Teresinha de Jesus Aguiar dos Santos,
Lima Rosália Maria Tôrres,
Reis Antonielly Campinho,
Silva Dulce Helena Siqueira,
Santos José Victor de Oliveira,
Menezes AgAnne Pereira Melo,
Mata Ana Maria Oliveira,
Dias Ana Carolina Soares,
Alencar Marcus Vinícius Oliveira Barros,
Paz Márcia Fernanda Correia Jardim,
Moreno Lina Clara Gayoso e Almendra Ibiapina,
Islam Muhammad Torequl,
Mubarak Mohammad S.,
Sousa João Marcelo de Castro e,
Melo Cavalcante Ana Amélia de Carvalho
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6830
Subject(s) - citrinin , dmba , bone marrow , apoptosis , cyclophosphamide , micronucleus test , penicillium citrinum , cytotoxic t cell , breast cancer , pharmacology , cancer , medicine , biology , immunology , cancer research , toxicity , chemotherapy , in vitro , carcinogenesis , mycotoxin , biochemistry , botany , food science
Breast cancer is one of the most lethal types of cancer and a leading cause of mortality among Women worldwide. Citrinin (CIT), a polyketide extracted from the fungus Penicillium citrinum , exhibits a wide range of biological activities such as antibacterial, antifungal, and cytotoxic effects. The aim of the current study was to evaluate the antitumoral effects of CIT against 7,12‐dimethylbenzanthracene (DMBA)‐induced mammary carcinoma in Swiss mice For this, CIT, DMBA and the standard cyclophosphamide (CPA) induced behavioral changes in experimental animals, and these changes were screened by using the rota rod and open field tests. Additionally, hematological, biochemical, immuno‐histochemical, and histopathological analyses were carried out. Results suggest that CIT did not alter behavioral, hematological, and biochemical parameters in mice. DMBA induced invasive mammary carcinoma and showed genotoxic effects in the breasts, bone marrow, lymphocytes, and hepatic cells. It also caused mutagenic effects in the formation of micronuclei, bridges, shoots, and binucleate cells in bone marrow and liver. CIT and CPA genotoxic effects were observed after 3 weeks of therapy, where CIT exhibited a repair capacity and induced significant apoptotic damage in mouse lymphocytes. In conclusion, CIT showed antitumoral effects in Swiss mice, possibly through induction of apoptosis.