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Effect of sour tea supplementation on liver enzymes, lipid profile, blood pressure, and antioxidant status in patients with non‐alcoholic fatty liver disease: A double‐blind randomized controlled clinical trial
Author(s) -
Izadi Fatemeh,
Farrokhzad Amirhosein,
Tamizifar Babak,
Tarrahi Mohammad Javad,
Entezari Mohammad Hassan
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6826
Subject(s) - medicine , placebo , blood pressure , triglyceride , nonalcoholic fatty liver disease , endocrinology , lipid profile , blood lipids , fatty liver , gastroenterology , cholesterol , disease , pathology , alternative medicine
The aim of this study was to evaluate the efficacy of sour tea supplementation in patients with nonalcoholic fatty liver disease (NAFLD). Seventy NAFLD patients were enrolled in this randomized, double‐blind, placebo‐controlled clinical trial. Participants received sour tea in the form of a 450 mg capsule or a placebo capsule daily for 8 weeks. Anthropometric indices, liver enzymes, lipid profile, blood pressure, and antioxidant status were evaluated at the baseline and at the end of the study. Sixty‐one participants completed the study. After 8 weeks, sour tea administration significantly decreased serum triglyceride (TG) ( p = .03), alanine aminotransferase (ALT) ( p = .01), and aspartate aminotransferase (AST) ( p = .004) levels compared with the placebo. In addition, sour tea supplementation resulted in a significant reduction in systolic blood pressure (SBP) ( p = .03) and diastolic blood pressure (DBP) ( p = .04), and a significant increase in serum total antioxidant capacity (TAC) levels ( p ˂ .001) compared with the placebo. However, no significant changes in anthropometric measures, total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐c), and high‐density lipoprotein cholesterol (HDL‐c) levels were observed after sour tea supplementation compared with the placebo ( p > .05). Sour tea supplementation may be effective in improving serum TG, liver enzymes, and blood pressure in patients diagnosed with NAFLD. Further studies are needed to address the exact mechanism of action of these effects.