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The effect of saffron supplementation on some inflammatory and oxidative markers, leptin, adiponectin, and body composition in patients with nonalcoholic fatty liver disease: A double‐blind randomized clinical trial
Author(s) -
Kavianipour Farnaz,
Aryaeian Naheed,
Mokhtare Marjan,
Mirnasrollahiparsa Reyhanesadat,
Jannani Leila,
Agah Shahram,
Fallah Sodabeh,
Moradi Nariman
Publication year - 2020
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6791
Subject(s) - adiponectin , medicine , nonalcoholic fatty liver disease , placebo , gastroenterology , leptin , malondialdehyde , oxidative stress , endocrinology , fatty liver , insulin resistance , obesity , pathology , disease , alternative medicine
Background Nonalcoholic fatty liver disease (NAFLD) is characterized by oxidative stress and inflammation in the hepatocytes . Saffron and its constituents are reported to have several properties such as anti‐inflammatory and anti‐diabetic effects. Materials and methods In a randomized double‐blind placebo‐controlled trial with two parallel groups including 76 eligible men and female patients with NAFLD aged 18–65, recruited from Hazrat Rasul Akram Hospital in Tehran, Iran. NAFLD was defined by a Gastroenterologist based on the American Gastrointestinal and Liver Association standards. Participants were randomly assigned to two groups receiving daily supplementation of either one tablet of 100 mg saffron ( n = 38) or one placebo ( n = 38) for 12 weeks. The primary outcome was high sensitive C‐reactive protein (hs‐CRP) and secondary outcomes were alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor alpha (TNF‐α), malondialdehyde (MDA), total anti‐oxidant capacity (TAC), leptin, adiponectin, anthropometric, and body composition Both groups were assigned similar diet and physical activity. Results In the treatment group, significant decreases in hs‐CRP (−1.80 ng/ml, 95% CI = −2.97, −0.63, p = .032), leptin (−0.27 ng/ml, 95% CI = −0.65, −0.10, p = .040), MDA (−1.01 ng/ml, 95% CI = −1.89, −0.14, p = .023) and significant increase in TAC (0.34 μmol/L, 95% CI = 0.08, 0.61, p = .011) were observed compared to the placebo group. However, there were no significant changes in serum alanine aminotransferase, AST, TNF‐α, body composition, and anthropometric indexes ( p  > .05). Conclusion In the present study, 12 weeks of 100 mg of saffron supplementation indicated beneficial effects on serum levels of some inflammatory, oxidative stress, and adipokines biomarkers but it had no significant effect on serum concentrations of liver enzymes, anthropometric, and body composition measurements.

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