Premium
Investigating the ameliorative effect of alpha‐mangostin on development and existing pain in a rat model of neuropathic pain
Author(s) -
Ghasemzadeh Rahbardar Mahboobeh,
Razavi Bibi Marjan,
Hosseinzadeh Hossein
Publication year - 2020
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6768
Subject(s) - neuropathic pain , medicine , pharmacology , hyperalgesia , allodynia , nociception , alpha (finance) , anesthesia , glutathione , spinal cord , lumbar spinal cord , chemistry , surgery , receptor , biochemistry , construct validity , psychiatry , patient satisfaction , enzyme
Mangosteen fruit has been used for various disorders, including pain. The effects of alpha‐mangostin, the main component of mangosteen, on the neuropathic pain caused by chronic constriction injury (CCI) were evaluated in rats. In treatment groups, alpha‐mangostin (10, 50, 100 mg/kg/day, i.p.) was administered from Day 0, the day of surgery, for 14 days. The degree of heat hyperalgesia, cold, and mechanical allodynia was assessed on Days 0, 3, 5, 7, 10, and 14. The lumbar spinal cord levels of MDA, GSH, inflammatory markers (TLR‐4, TNF‐α, MMP2, COX2, IL‐1β, iNOS, and NO), apoptotic markers (Bcl‐2, Bax, and caspase‐3) were measured by western blot on Days 7 and 14. Rats in the CCI group showed thermal hyperalgesia, cold, and mechanical allodynia on Days 3–14. All concentrations of alpha‐mangostin alleviated CCI‐induced behavioral alterations. MDA level augmented and GSH level decreased in the CCI group and alpha‐mangostin (50, 100 mg/kg) reversed the alterations. An enhancement in the levels of all inflammatory markers, Bax, and caspase‐3 was shown on Days 7 and 14, which was controlled by alpha‐mangostin (50 mg/kg). The detected antinociceptive effects of alpha‐mangostin may be mediated through antioxidant, anti‐inflammatory, and antiapoptotic properties.