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Pharmacological studies on the antinociceptive, anxiolytic and antidepressant activity of Tinospora crispa
Author(s) -
Rakib Ahmed,
Ahmed Shahriar,
Islam Md. Ashiqul,
Uddin Mir Muhammad Nasir,
Paul Arkajyoti,
Chy Md. Nazim Uddin,
Emran Talha Bin,
Seidel Veronique
Publication year - 2020
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6725
Subject(s) - licking , anxiolytic , elevated plus maze , open field , nociception , pharmacology , chemistry , tinospora cordifolia , analgesic , antidepressant , traditional medicine , medicine , anxiety , biochemistry , receptor , psychiatry
Pharmacological studies were performed in mice on the methanol extract of Tinospora crispa (TC), and of its hexane (HF) and chloroform (CF) fractions. Significant antinociceptive activity was observed for TC, HF, and CF in the acetic acid‐induced writhing and formalin‐induced paw licking tests. Anxiolytic and antidepressant activities were assessed using the open field, hole board, and elevated plus maze (EPM) tests. TC, HF, and CF demonstrated a significant decrease in spontaneous locomotor activity. They also showed an increase in the number of head‐dippings in the hole‐board test, suggesting decreased fearfulness. TC, and most of its fractions, showed a significant increase of the time spent in the opened arm of the EPM, indicating reduced anxiety. This study provides some support to explain the traditional use of T. crispa as a remedy for pain.