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Application of curcumin and its derivatives in tumor multidrug resistance
Author(s) -
Xu Ting,
Guo Pu,
He Yingmeng,
Pi Chao,
Wang Yuanyuan,
Feng Xianhu,
Hou Yi,
Jiang Qingsheng,
Zhao Ling,
Wei Yumeng
Publication year - 2020
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6694
Subject(s) - curcumin , multiple drug resistance , chemotherapy , pharmacology , tumor cells , medicine , mechanism (biology) , drug resistance , cancer research , biology , microbiology and biotechnology , philosophy , epistemology
Malignant tumor endangers seriously the health of all mankind. Multidrug resistance (MDR) is one of the main causes of clinical tumor chemotherapy failure. Curcumin (CUR) has not only antitumor activity but also reversing tumor MDR effect. CUR reverses tumor MDR via regulating related signal pathways or corresponding expressed proteins or gene. When combined with chemotherapeutic agents, CUR can be a chemotherapeutic sensitive agent to enhance chemotherapy efficacy and weaken tumor MDR. On the other hand, to improve the MDR reversal effect of CUR, its derivatives have been extensively studied. Therefore, this article mainly focuses on reviewing the application of CUR and its derivatives in MDR and its mechanism of reversing MDR.