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Protective effects of naringin against drugs and chemical toxins induced hepatotoxicity: A review
Author(s) -
Shirani Kobra,
Yousefsani Bahare Sadat,
Shirani Maryam,
Karimi Gholamreza
Publication year - 2020
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6641
Subject(s) - naringin , pharmacology , oxidative stress , lipid peroxidation , antioxidant , glutathione , drug , liver injury , flavonoid , drug metabolism , xenobiotic , medicine , chemistry , traditional medicine , biochemistry , enzyme , chromatography
The liver is a vital metabolic organ for drug and xenobiotic metabolism which is influenced by chemical and natural toxins. Liver injury is associated with systemic oxidative stress, which leads to cellular necrosis, fibrosis, tissue lipid peroxidation, and depletion in glutathione levels. Considering the lack of reliable hepato‐protective drugs in modern medicine, plant‐derived phytoconstituents seem to be a noteworthy option. Naringin is an abundant flavonoid found in citrus fruits with various pharmacological benefits such as antioxidant, anti‐inflammatory, and antiapoptotic, activities. In this review, we summarize available data from recent studies about the hepatoprotective effects of naringin against chemical toxicants and discuss the possible mechanisms of actions.