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Impact of flaxseed supplementation on plasma lipoprotein(a) concentrations: A systematic review and meta‐analysis of randomized controlled trials
Author(s) -
Hadi Amir,
Askarpour Moein,
Ziaei Rahele,
Venkatakrishnan Kamesh,
Ghaedi Ehsan,
Ghavami Abed
Publication year - 2020
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6640
Subject(s) - meta analysis , randomized controlled trial , medicine , cochrane library , placebo , subgroup analysis , web of science , lipoprotein , lipoprotein(a) , plasma levels , gastroenterology , cholesterol , alternative medicine , pathology
The aim of the study was to investigate the impact of supplementation with flaxseed on plasma lipoprotein(a) [Lp(a)] levels through a systematic review and meta‐analysis of eligible randomized placebo‐controlled trials. PubMed, Scopus, Cochrane Library, and ISI Web of Science were searched for randomized controlled trials (RCTs) which have been published up to November 2019. RCTs that investigated the effect of flaxseed supplementation on plasma Lp(a) levels in adults were included for final analysis. The random effects model was used for calculating the overall effects. Meta‐analysis of 7 selected RCTs with 629 individuals showed significant lowering effect of flaxseed supplementation on Lp(a) (MD −2.06 mg/dl; 95% CI: −3.846, −0.274, p = .024), without considerable heterogeneity between studies ( p = .986, I 2 = 0%). Subgroup analysis also revealed that longer duration only showed significant lowering effect of flaxseed supplementation on Lp(a). This meta‐analysis has shown that flaxseed supplementation might significantly decrease plasma Lp(a) levels. Future well‐designed and long‐term clinical trials are required to confirm these results.