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Effect of Cichorium intybus seeds supplementation on the markers of glycemic control, oxidative stress, inflammation, and lipid profile in type 2 diabetes mellitus: A randomized, double‐blind placebo study
Author(s) -
Chandra Kailash,
Jain Vineet,
Jabin Azhar,
Dwivedi Shridhar,
Joshi Santosh,
Ahmad Sayeed,
Jain Swatantra K.
Publication year - 2020
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6624
Subject(s) - medicine , glycemic , placebo , oxidative stress , diabetes mellitus , metformin , type 2 diabetes mellitus , cichorium , type 2 diabetes , gastroenterology , randomized controlled trial , lipid profile , endocrinology , biology , pathology , alternative medicine , agronomy
Diabetes mellitus is associated with increased levels of inflammation and oxidative stress in patients. The aim of the present study was to test the hypothesis that aqueous extract of Cichorium intybus seeds (AECIS) would have add‐on beneficial effect in type 2 diabetes mellitus (T2DM). In this double‐blind randomized clinical study, 150 subjects were enrolled to assess the add‐on efficacy and safety of AECIS in T2DM patients. The subjects were randomized (1:1) to the AECIS ( n = 51) and placebo ( n = 49) groups. The subjects in both groups continued to take prescribed doses of metformin. The standardization of AECIS was carried out by liquid chromatography–mass spectrometry and phytochemical analysis. The mean hemoglobin A1c (HbA1c) level in the AECIS and placebo groups at baseline was 8.6% and 8.5%, respectively. Mean values of HbA1c at the end of 12 weeks of intervention were 7.42% in the AECIS group (a reduction of 1.18% from baseline) and 8.4% in the placebo group (mean reduction of 0.1% from baseline). Besides, significant reduction in inflammation, oxidative stress, and hypertriglyceridemia was seen in the AECIS group ( p < .05). The study shows for the first time that AECIS supplementation ameliorates the disease progression and it is beneficial as a potential adjunct dietary supplement for the management of T2DM.