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Ilex paraguariensis , white mulberry and chromium picolinate in patients with pre‐diabetes
Author(s) -
Derosa Giuseppe,
D’Angelo Angela,
Maffioli Pamela
Publication year - 2020
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6611
Subject(s) - nutraceutical , glycemic , placebo , medicine , diabetes mellitus , insulin resistance , traditional medicine , pharmacology , endocrinology , alternative medicine , pathology
Aim to evaluate if a nutraceutical compound containing Ilex paraguariensis , White Mulberry and Chromium Picolinate can ameliorate glycemic status in patients with pre‐diabetes. Methods we enrolled patients with IFG or IGT, not taking other hypoglycemic compounds. Patients were randomized to take placebo or the nutraceutical compound for 3 months, in a randomized, double‐blind, placebo‐controlled design. Both treatments were self‐administered once a day, 1 tablet during the breakfast. Results a reduction of FPG was observed with the nutraceutical combination (−7.8%). Furthermore, there was a decrease of HOMA‐IR with the nutraceutical combination (−7.9%). M value was higher ( p < 0.05 vs baseline and p < 0.05 vs placebo) at the end of the treatment. We obtained a reduction of Tg with the nutraceutical combination (−8.3%). About 16.6% of patients treated with nutraceutical returned to have a normal glycemia (< 100 mg/dL), and all patients had an improvement of insulin‐resistance, in particular 67% of patients returned to have a M value inside range of normal insulin sensitivity. Conclusions a nutraceutical containing Ilex paraguariensis , White Mulberry and Chromium Picolinate at 500 mg can be helpful in improving glycemia and Tg value, in patients with pre‐diabetes.

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