Premium
Tart cherry ( Prunus cerasus L. ) fractions inhibit biofilm formation and adherence properties of oral pathogens and enhance oral epithelial barrier function
Author(s) -
Ben Lagha Amel,
LeBel Geneviève,
Grenier Daniel
Publication year - 2020
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6574
Subject(s) - fusobacterium nucleatum , streptococcus mutans , biofilm , microbiology and biotechnology , antimicrobial , candida albicans , chemistry , prunus cerasus , population , corpus albicans , biology , bacteria , medicine , botany , sour cherry , genetics , environmental health , porphyromonas gingivalis , cultivar
Dental caries, candidiasis, and periodontal disease are the most common oral infections affecting a wide range of the population worldwide. The present study investigated the effects of two tart cherry ( Prunus cerasus L.) fractions on important oral pathogens, including Candida albicans , Streptococcus mutans , and Fusobacterium nucleatum , as well as on the barrier function of oral epithelial cells. Procyanidins and quercetin and its derivatives were the most important constituents found in the tart cherry fractions. Although the fractions showed poor antimicrobial activity, they inhibited biofilm formation by the three oral pathogens in a dose‐dependent manner. The tart cherry fractions also attenuated the adherence of C. albicans and S. mutans to a hydroxylapatite surface as well as the adherence of F. nucleatum to oral epithelial cells. Treating oral epithelial cells with the tart cherry fractions significantly enhanced the barrier function as determined by monitoring the transepithelial electrical resistance. In conclusion, this study showed that the tart cherry fractions and their bioactive constituents could be promising antiplaque compounds by targeting biofilm formation and adherence properties of oral pathogens. Furthermore, its property of increasing the epithelial barrier function may protect against microbial invasion of the underlying connective tissue.