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Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome
Author(s) -
Ahamad Javed,
Toufeeq Ibrahim,
Khan Mohammad Ahmed,
Ameen Muath Sh. Mohammed,
Anwer Esra T.,
Uthirapathy Subha,
Mir Showkat R.,
Ahmad Javed
Publication year - 2019
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6511
Subject(s) - oleuropein , hydroxytyrosol , olea , oleaceae , antioxidant , olive leaf , traditional medicine , chemistry , mediterranean diet , biology , botany , polyphenol , biochemistry , food science , medicine , pathology
Olive ( Olea europaea Linn., Fam. Oleaceae) is commonly known as Zaytoon in Mediterranean region. Its fruits and oil are essential components of Mediterranean diets. Olive tree is a prevalent plant species and one of the important cultivated crops of Mediterranean region. Oleuropein is a phenolic constituents of olive, which, along with its related compounds, has been indicated to be majorly responsible for its beneficial effects. Oleuropein is a secoiridoid type of phenolic compound and consists of three structural subunits: hydroxytyrosol, elenolic acid, and a glucose molecule. It is also reported to be the chemotaxonomic marker of olive. The oleuropein is reported to possess a number of biological activities including action against dyslipidemia, antiobesity, antidiabetic, antioxidant, antiatherogenic, antihypertensive, antiinflammatory, and hepatoprotective actions. The scientific evidence supports the role of oleuropein as a potential agent against metabolic syndrome. The present review discusses chemistry of oleuropein along with potential role of oleuropein with reference to pathophysiology of metabolic syndrome.