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Parthenolide ameliorates intracerebral hemorrhage‐induced brain injury in rats
Author(s) -
Wang Junan,
Tong Mingliang,
Zhao Bin,
Zhu Gang,
Xi Donghua,
Yang Jianping
Publication year - 2020
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6510
Subject(s) - neuroprotection , proinflammatory cytokine , parthenolide , pharmacology , neuroinflammation , oxidative stress , glutathione , intracerebral hemorrhage , medicine , superoxide dismutase , tlr4 , inflammation , endocrinology , chemistry , apoptosis , biochemistry , enzyme , subarachnoid hemorrhage
Neuroinflammation and oxidative stress are key contributors to intracranial hemorrhage (ICH)‐induced brain injury. Parthenolide (PN) is a sesquiterpene lactone that has been observed to have antioxidative, anti‐inflammatory, and neuroprotective potentials. However, the role of PN in ICH remains unclear. Therefore, we investigated the neuroprotective effects and underlying mechanisms of PN on an experimental model of ICH in rats. Our results showed that PN treatment improved neurological deficit and brain edema in ICH rats. The ipsilateral hemispheres of the brain were separated and homogenized. The concentrations of TNF‐α, interleukin (IL)‐6, and IL‐17 in the homogenates were detected by enzyme‐linked immunosorbent assay. We found that PN inhibited the production of proinflammatory cytokines in an ICH rat model. The ROS and glutathione (GSH) levels, as well as the activity of superoxide dismutase (SOD) in the homogenates were measured. ICH caused an increase in ROS level, and the decreases in GSH level and SOD activity were mitigated by PN treatment. Furthermore, PN significantly suppressed the expressions of active caspase‐3 and Bax in ipsilateral hemispheres of the brain at Day 3 after ICH, as well as increased the surviving neurons. Finally, the ICH‐induced activation of TLR4/NF‐κB pathway was suppressed by PN treatment. These findings suggested that PN could be beneficial in the therapeutic strategy for ICH treatment.