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Palmatine: A review of pharmacological properties and pharmacokinetics
Author(s) -
Tarabasz Dominik,
KukulaKoch Wirginia
Publication year - 2020
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6504
Subject(s) - palmatine , berberine , traditional medicine , menispermaceae , berberidaceae , ranunculaceae , alkaloid , medicine , benzylisoquinoline , sanguinarine , isoquinoline , pharmacology , biology , botany , chemistry , biochemistry , medicinal chemistry , biosynthesis , enzyme
The aim of this review is to collect together the results of the numerous studies over the last two decades on the pharmacological properties of palmatine published in scientific databases like Scopus and PubMed, which are scattered across different publications. Palmatine, an isoquinoline alkaloid from the class of protoberberines, is a yellow compound present in the extracts from different representatives of Berberidaceae, Papaveraceae, Ranunculaceae, and Menispermaceae . It has been extensively used in traditional medicine of Asia in the treatment of jaundice, liver‐related diseases, hypertension, inflammation, and dysentery. New findings describe its possible applications in the treatment of civilization diseases like central nervous system‐related problems. This review intends to let this alkaloid come out from the shade of a more frequently described alkaloid: berberine. The toxicity, pharmacokinetics, and biological activities of this protoberberine alkaloid will be developed in this work.