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A systematic review on hepatoprotective activity of quercetin against various drugs and toxic agents: Evidence from preclinical studies
Author(s) -
Pingili Ravindra Babu,
Challa Siva Reddy,
Pawar A. Krishnamanjari,
Toleti Vyshnavi,
Kodali Tanvija,
Koppula Sirisha
Publication year - 2020
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6503
Subject(s) - chemistry , quercetin , pharmacology , traditional medicine , antioxidant , biochemistry , medicine
Quercetin is one of the most abundant flavonoids in human diet that has been reported to exhibit a wide range of pharmacological properties. The biochemical and molecular mechanisms involved in the hepatoprotective activity of quercetin were discussed in this review. Quercetin exhibited hepatoprotective activity against 2‐butoxyethanol, acrylamide, acrylonitrile, aflatoxin B1, aroclor‐1254, arsenic, sodium arsenite, azathioprine, cadmium chloride, carbon tetrachloride, chlorpyrifos, cyclosporine A, diazinon, dimethylnitrosamine, doxorubicin, epirubicin, ethanol, fenvalerate, isoniazide, rifampicin, lead acetate, lindane, D ‐galactosamine, methotrexate, methylmercury, nickel sulfate, paracetamol, perfluorooctanoic acid, polychlorinated biphenyls, pyrrolizidine alkaloid clivorine, rotenone, sodium fluoride, streptazotocin, tert ‐butyl hydroperoxide, thioacetamide, titanium dioxide, tumor necrosis factor‐α, tripterygium glycoside, triptolide, ultraviolet A light, concavalin A, bisphenol, and ischemia‐induced hepatotoxicity in various animal models due to its antioxidant, free radical‐scavenging,anti‐inflammatory, antiapoptotic, and cytochrome P450 2E1 (CYP2E1) inhibitory activities. In this review, we provide an overview of the possible mechanisms by which quercetin reduced the hepatotoxicity of different hepatotoxicants. This will help the toxicologists, pharmacologists, and chemists to develop new safer pharmaceutical products with quercetin and other hepatotoxicants.