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Corn silk decoction for blood lipid in patients with angina pectoris: A systematic review and meta‐analysis
Author(s) -
Shi Shihua,
Yu Baili,
Li Weihao,
Shan Jiayue,
Ma Tianhong
Publication year - 2019
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6474
Subject(s) - decoction , medicine , meta analysis , angina , randomized controlled trial , traditional medicine , blood lipids , high density lipoprotein , cholesterol , lipid profile , myocardial infarction
The aims of this study were to evaluate the efficacy of corn silk decoction on lipid profile in patients with angina pectoris. PubMed, Cochrane, Embase, Google Scholar, Chongqing VIP Chinese Science and Technology Periodical Database, China National Knowledge Infrastructure, and Wanfang database were searched up to January 2019 for randomized controlled trials that assessed the impact of corn silk decoction on total cholesterol, triglycerides, low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol in patients with angina pectoris. Study evaluation and synthesis methods were in accordance with the Cochrane Handbook, and data were analyzed using Review Manager (version 5.3) software. Random effects model was applied in this systematic review and meta‐analysis to compensate for potential heterogeneity among the included studies. A total of four randomized controlled trials were eligible for meta‐analysis. Pooled results of these studies indicated that corn silk decoction might improve high‐density lipoprotein cholesterol and reduce total cholesterol, triglycerides, and low‐density lipoprotein cholesterol in patients with angina pectoris. Subgroup analyses showed that corn silk decoction or modified corn silk decoction plus conventional pharmaceutical treatment could have favorable effects on blood lipids. However, the lack of blinding in most studies may have led to overestimation of these effects. Further studies with better design are needed to confirm these findings.