Premium
β‐Elemene inhibits peritoneal metastasis of gastric cancer cells by modulating FAK/Claudin‐1 signaling
Author(s) -
Deng Mingming,
Zhang Ye,
Liu Bofang,
Chen Yang,
Song Huicong,
Yu Ruoxi,
Che Xiaofang,
Qu Xiujuan,
Liu Yunpeng,
Hu Xuejun,
Xu Xiuying
Publication year - 2019
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6436
Subject(s) - elemene , cancer , metastasis , cancer research , medicine , in vivo , cancer cell , in vitro , pathology , apoptosis , biology , biochemistry , microbiology and biotechnology
Peritoneal metastasis is common in advanced gastric cancer patients and is typically associated with a worse prognosis. β‐Elemene is a natural compound that can be isolated from the Curcuma wenyujin plant and has been widely used in China to treat a variety of cancers. However, the anti‐metastatic impacts of β‐elemene on gastric cancer remain unknown. In our study, we found that β‐elemene significantly inhibited the migration and invasive capacity of gastric cells in vitro and inhibited the capacity of gastric cancer cells to peritoneally diffuse and metastasize in vivo. Mechanistically, we demonstrated that the anti‐metastatic effects of β‐elemene were exerted by downregulating the expression of Claudin‐1. Furthermore, β‐elemene was found to inhibit the metastatic capacity of cells by downregulating FAK phosphorylation, which regulated Claudin‐1. Overall, our result revealed that β‐elemene inhibited peritoneal metastases from gastric cancer by modulating the FAK/Claudin‐1 pathway.