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Effect of Nigella sativa (black seed) supplementation on glycemic control: A systematic review and meta‐analysis of clinical trials
Author(s) -
Askari Gholamreza,
Rouhani Mohammad Hossein,
Ghaedi Ehsan,
Ghavami Abed,
Nouri Mehran,
Mohammadi Hamed
Publication year - 2019
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6337
Subject(s) - nigella sativa , glycemic , medicine , meta analysis , postprandial , cochrane library , subgroup analysis , glycemic index , randomized controlled trial , diabetes mellitus , gastroenterology , traditional medicine , insulin , endocrinology
This study was aimed to quantify the antihyperglycemic effect of Nigella sativa ( N . sativa ). An in‐depth search to identify clinical trials investigating the impact of N . sativa on glycemic indices via MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Library, and Google scholar databases were performed up to November 2018. We used a random effects model to estimate pooled effect size of fasting plasma glucose (FPG), postprandial blood glucose (PPBG), and hemoglobin A1c (HbA1c). A total of 17 randomized controlled trials investigating the effects of N . sativa on FPG, PPBG, and HbA1c were included. Meta‐analysis suggested a significant association between N . sativa supplementation and reduction in FPG (weighted mean difference [WMD]: −9.93 mg/dl, 95% CI [−13.44, −6.41]), PPBG (WMD: −14.79 mg/dl, 95% CI [−24.19, −5.39]), and HbA1c (WMD: −0.57%, 95% CI [−0.77, −0.37]). Subgroup analysis revealed that N . sativa oil was more effective than N . sativa powder in reduction of FPG. To sum up, N . sativa consumption has a significant lowering effect on glycemic status. Further studies with prolonged durations and powerful design are needed to specify the exact mechanism, optimal dosage, and duration of N . sativa supplementation to obtain a beneficial effect on glycemic status.