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Effects of turmeric and curcumin on oral mucositis: A systematic review
Author(s) -
Normando Ana Gabriela Costa,
Menêses Amanda Gomes,
Toledo Isabela Porto,
Borges Gabriel Álvares,
Lima Caroline Lourenço,
Reis Paula Elaine Diniz,
Guerra Eliete Neves Silva
Publication year - 2019
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6326
Subject(s) - mucositis , medicine , curcumin , cochrane library , meta analysis , medline , randomized controlled trial , systematic review , traditional medicine , dermatology , radiation therapy , pharmacology , political science , law
The aim of this study was to evaluate the effects of turmeric and curcumin in the management of oral mucositis in cancer patients undergoing chemo and/or radiotherapy. The systematic review was reported according to the Preferred Reporting Items for Systematic reviews and Meta‐Analyses. The search was performed in the following database: Cochrane Library, LILACS, LIVIVO, PubMed, Scopus, and Web of Science. A gray literature search was undertaken using Google Scholar, Open Grey, and ProQuest. The methodology of included studies was evaluated by the Meta‐Analysis of Statistics Assessment and Review Instrument. After a two‐step selection process, four randomized and one nonrandomized clinical trials were included in the analysis. Two studies were categorized as low and three as moderate risk of bias. Turmeric/curcumin was applied topically as a gel or as a mouthwash. Patients treated with turmeric/curcumin experienced reduced grade of mucositis, pain, erythema intensity, and ulcerative area. Current evidence suggests that topical application of turmeric or curcumin is effective in controlling signs and symptoms of oral mucositis. Thus, further investigation is required to confirm the promising effect of turmeric and curcumin in oral inflammatory lesions.