Premium
Pheophorbide A from Gelidium amansii improves postprandial hyperglycemia in diabetic mice through α‐glucosidase inhibition
Author(s) -
Kim Min Jung,
Kim Hak Ju,
Han Ji Sook
Publication year - 2019
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6260
Subject(s) - pheophorbide a , postprandial , acarbose , endocrinology , medicine , carbohydrate , streptozotocin , chemistry , diabetes mellitus , photodynamic therapy , organic chemistry
This study was designed to determine the inhibitory effects of pheophorbide A on carbohydrate digesting enzymes and its ability to improve postprandial hyperglycemia in streptozotocin (STZ)‐induced diabetic mice. Pheophorbide A caused noticeable inhibitory effects on α‐glucosidase and α‐amylase, with half‐maximal inhibitory concentrations (IC 50 ) of 80.65 ± 5.90 and 76.48 ± 6.31 μM, respectively. The pheophorbide‐mediated inhibition of α‐glucosidase and α‐amylase was significantly more effective than that of the positive control, acarbose. The increase in postprandial blood glucose levels was more significantly suppressed in the pheophorbide A group than in the control group of STZ‐induced diabetic mice. In addition, the area under the curve was decreased by pheophorbide A intake in STZ‐induced diabetic mice. Our results suggested that pheophorbide A may help to improve postprandial hyperglycemia by inhibiting the activity of carbohydrate digesting enzymes.