Premium
The effects of quercetin supplementation on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome
Author(s) -
Khorshidi Masoud,
Moini Ashraf,
Alipoor Elham,
Rezvan Neda,
GorganiFiruzjaee Sattar,
Yaseri Mehdi,
HosseinzadehAttar Mohammad Javad
Publication year - 2018
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6166
Subject(s) - medicine , endocrinology , resistin , polycystic ovary , insulin resistance , homeostatic model assessment , testosterone (patch) , adiponectin , placebo , luteinizing hormone , metabolic syndrome , insulin , hormone , obesity , alternative medicine , pathology
The aim of this study was to investigate the effect of quercetin on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome (PCOS). In this randomized, double‐blind, placebo‐controlled trial, 78 overweight or obese women (25 ≤ BMI ≤ 40 kg/m 2 , 20–40 years) with PCOS were recruited. Patients were randomized to receive 1,000 mg/day quercetin or placebo for 12 weeks. Resistin plasma concentration and gene expression in peripheral blood mononuclear cells, parameters of glucose homeostasis, circulatory testosterone, luteinizing hormone (LH), and sex hormone‐binding globulin, and anthropometries were assessed at baseline and at the end of the study. Following supplementation, quercetin significantly decreased resistin concentration (2.07 ± 0.23 vs. 2.88 ± 0.40 ng/ml, p < 0.001) and mRNA level (0.64 ± 0.58 vs. 1 ± 0.56 fold change, p = 0.008), compared with placebo group. Moreover, testosterone (0.72 ± 0.15 vs. 0.76 ± 0.12 ng/ml, p = 0.001) and LH (8.05 ± 2.88 vs. 8.77 ± 1.99 mIU/ml, p = 0.035) concentrations were significantly lower in quercetin compared with placebo group. Fasting blood glucose ( p < 0.001), insulin ( p = 0.02), and homeostatic model assessment of insulin resistance ( p = 0.009) decreased within the quercetin group; however, no significant differences were observed compared with the placebo group ( p = 0.074, p = 0.226, p = 0.22, respectively). Quercetin supplementation decreased resistin plasma levels and gene expression, and testosterone and LH concentration in overweight or obese women with PCOS.