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Effects of cannabidiol, a Cannabis sativa constituent, on oral wound healing process in rats: Clinical and histological evaluation
Author(s) -
Klein Mariana,
Quadros De Bortolli Juliane,
Guimarães Francisco Silveira,
Salum Fernanda Gonçalves,
Cherubini Karen,
Figueiredo Maria Antonia Zancanaro
Publication year - 2018
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6165
Subject(s) - cannabidiol , medicine , wound healing , cannabis sativa , tongue , in vivo , oral administration , pharmacology , surgery , cannabis , pathology , biology , botany , microbiology and biotechnology , psychiatry
The effects of cannabidiol (CBD), the main non‐psychotropic component of Cannabis sativa , were assessed on oral wound healing in an in vivo model. Standardized ulcers were induced in 60 Wistar rats using a 5‐mm biopsy punch on the midline of the ventral tongue. Animals received intraperitoneal injections of CBD at doses of 0 (control), 5, and 10 mg/kg daily. Animals were weighed daily, and wound healing was clinically and histologically evaluated after 3 and 7 days of treatment. CBD treatment did not influence the wound area of ulcerative lesions at either observation time. Conversely, microscopic findings revealed that at Day 3 postwounding, CBD‐treated lesions exhibited significantly lower inflammatory scores than those in the control group. However, this difference was not observed at Day 7. Collectively, these findings indicate that CBD exert an antiinflammatory effect in early phase of wound healing process although it was not sufficient promote clinical improvement of oral traumatic ulcerative lesions.