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Protective and therapeutic potential of ginger ( Zingiber officinale ) extract and [6]‐gingerol in cancer: A comprehensive review
Author(s) -
Lima Rosália Maria Tôrres,
Reis Antonielly Campinho,
Menezes AgAnne Pereira Melo,
Santos José Victor de Oliveira,
Filho José Williams Gomes de Oliveira,
Ferreira José Roberto de Oliveira,
Alencar Marcus Vinícius Oliveira Barros,
Mata Ana Maria Oliveira Ferreira,
Khan Ishaq N.,
Islam Amirul,
Uddin Shaikh Jamal,
Ali Eunüs S.,
Islam Muhammad Torequl,
Tripathi Swati,
Mishra Siddhartha Kumar,
Mubarak Mohammad S.,
MeloCavalcante Ana Amélia de Carvalho
Publication year - 2018
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6134
Subject(s) - zingiber officinale , gingerol , pharmacology , mapk/erk pathway , oxidative stress , cancer cell , signal transduction , p38 mitogen activated protein kinases , cancer , chemistry , medicine , traditional medicine , biology , biochemistry , botany
Natural dietary agents have attracted considerable attention due to their role in promoting health and reducing the risk of diseases including cancer. Ginger, one of the most ancient known spices, contains bioactive compounds with several health benefits. [6]‐Gingerol constitutes the most pharmacologically active among such compounds. The aim of the present work was to review the literature pertaining to the use of ginger extract and [6]‐gingerol against tumorigenic and oxidative and inflammatory processes associated with cancer, along with the underlying mechanisms of action involved in signaling pathways. This will shed some light on the protective or therapeutic role of ginger derivatives in oxidative and inflammatory regulations during metabolic disturbance and on the antiproliferative and anticancer properties. Data collected from experimental (in vitro or in vivo) and clinical studies discussed in this review indicate that ginger extract and [6]‐gingerol exert their action through important mediators and pathways of cell signaling, including Bax/Bcl2, p38/MAPK, Nrf2, p65/NF‐κB, TNF‐α, ERK1/2, SAPK/JNK, ROS/NF‐κB/COX‐2, caspases‐3, ‐9, and p53. This suggests that ginger derivatives, in the form of an extract or isolated compounds, exhibit relevant antiproliferative, antitumor, invasive, and anti‐inflammatory activities.