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Electrocardiographic effects of hawthorn ( Crataegus oxyacantha ) in healthy volunteers: A randomized controlled trial
Author(s) -
Trexler Stephanie E.,
Nguyen Elaine,
Gromek Samantha M.,
Balunas Marcy J.,
Baker William L.
Publication year - 2018
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6094
Subject(s) - placebo , medicine , qt interval , crataegus , adverse effect , randomized controlled trial , anesthesia , clinical endpoint , qrs complex , electrocardiography , cardiology , traditional medicine , alternative medicine , pathology
The objective of this study was to evaluate the electrocardiographic effects of hawthorn in healthy adult volunteers. It was double‐blind cross‐over trial randomized 20 healthy adult volunteers to receive either a single oral 160‐mg dose of hawthorn or matching placebo. Triplicate 12‐lead electrocardiograms were taken before treatment and at 1‐, 2‐, 4‐, and 6‐hr post‐dose. Following at least a 7‐day washout period, participants were crossed over to the opposing treatment arm and had the measurements repeated. The primary endpoint was the change in corrected (Fridericia) QT intervals (QT c I) at 4 and 6 hr. Maximum post‐dose QT c I and changes in PR and QRS intervals were measured. No significant differences in 4‐ or 6‐hr QT c I were seen between hawthorn and placebo. Maximum post‐dose QT c I in the hawthorn and placebo groups were similar (346 ± 35 vs 346 ± 40 ms; p = .979). No significant adverse events were seen. In conclusion, a single dose of oral hawthorn had no effect on electrocardiographic parameters in healthy volunteers.