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Phytotherapeutics in cancer invasion and metastasis
Author(s) -
Salehi Bahare,
Zucca Paolo,
SharifiRad Mehdi,
Pezzani Raffaele,
Rajabi Sadegh,
Setzer William N.,
Varoni Elena Maria,
Iriti Marcello,
Kobarfard Farzad,
SharifiRad Javad
Publication year - 2018
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6087
Subject(s) - metastasis , cancer , angiogenesis , drug discovery , carcinogenesis , computational biology , medicine , disease , biology , cancer research , bioinformatics
Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.