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Experimental and clinical antihypertensive activity of Matricaria chamomilla extracts and their angiotensin‐converting enzyme inhibitory activity
Author(s) -
Awaad Amani A.,
ElMeligy Reham M.,
Zain Ghada M.,
Safhi Amal A.,
AL Qurain Noura A.,
Almoqren Shekhah S.,
Zain Yara M.,
Sesh Adri Vidya D.,
AlSaikhan Fahad I.
Publication year - 2018
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6086
Subject(s) - matricaria chamomilla , captopril , blood pressure , oral administration , glutathione , pharmacology , medicine , superoxide dismutase , chemistry , angiotensin converting enzyme , traditional medicine , enzyme , endocrinology , oxidative stress , biochemistry
Three different extracts of Matricaria chamomilla L. were evaluated for their antihypertensive activity, these extracts were total alcohol extract (Extract 1), oil extracted (Extract 2), and water lifted after oil extraction (Extract 3). Quantitative and Qualitative analyses were carried out for all extracts. The 3 extracts were proved to be safe for human use. A single oral administration of the plant extracts (200 mg/kg) decreases both systolic and diastolic blood pressure of normotensive rats after 1, 1.5, and 2 hr. Furthermore, groups treated with the evaluated extracts (100 & 200 mg/kg) or Captopril (20 mg/kg) showed a significant reduction in the elevated blood pressure and heart rate. Extract 3 showed the most antihypertensive activity. Serum biochemical parameters and lipid profile levels of treated groups were improved in comparison with induced‐hypertensive untreated rats. In evaluation of oxidative damage parameters Glutathione and superoxide dismutase ( SOD ) in some organs, the investigated extracts or captopril restored the amount of reduced Glutathione in tissues in addition to an increase in the activity of the SOD after a significant depletion of SOD activity. In the clinical study, there was a significant dose dependent decrease in Systolic blood pressure, Diastolic blood pressure, and heart rate compared with their basal values in both normotensive and hypertensive human volunteers after oral administration of Matricaria chamomilla beverages.