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A phytomodulatory hydrogel with enhanced healing effects
Author(s) -
Vasconcelos Mirele S.,
Souza Tamiris F.G.,
Figueiredo Ingrid S.,
Sousa Emília T.,
Sousa Felipe D.,
Moreira Renato A.,
Alencar Nylane M.N.,
LimaFilho José V.,
Ramos Márcio V.
Publication year - 2018
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6018
Subject(s) - wound healing , granulation tissue , myeloperoxidase , neovascularization , medicine , chemistry , angiogenesis , inflammation , surgery , immunology
The healing performance of a hydrogel composed of hemicelluloses extracted from seeds of Caesalpinia pulcherrima (Fabaceae) and mixed with phytomodulatory proteins obtained from the latex of Calotropis procera was characterized on excisional wounds. The hydrogel did not induce dermal irritability. When topically used on excisional wounds, the hydrogel enhanced healing by wound contraction. Histology and the measurement of inflammatory mediators (myeloperoxidase, interleukin‐1β, and interleukin‐6) suggested that the inflammatory phase of the healing process was intensified, stimulating fibroplasia and neovascularization (proliferative phase) and tissue remodeling by increasing new collagen fiber deposition. In addition, reduction on levels of malondialdehyde in the groups that the hydrogel was applied suggested that the oxidative stress was reduced. The hydrogel performed better than the reference drug used, as revealed by the extended thickness of the remodeled epithelium.