Premium
Lonicera japonica Thunb. Induces caspase‐dependent apoptosis through death receptors and suppression of AKT in U937 human leukemic cells
Author(s) -
Park Cheol,
Lee Won Sup,
Han MinHo,
Song Kyoung Seob,
Hong SuHyun,
Nagappan Arulkumar,
Kim GiYoung,
Kim Gon Sup,
Jung JinMyung,
Ryu Chung Ho,
Shin Sung Chul,
Hong Soon Chan,
Choi Yung Hyun
Publication year - 2018
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5996
Subject(s) - xiap , apoptosis , u937 cell , protein kinase b , pi3k/akt/mtor pathway , caspase , japonica , downregulation and upregulation , receptor , pharmacology , programmed cell death , cancer research , biology , chemistry , biochemistry , botany , gene
Decoctions obtained from the dried flowers of Lonicera japonica Thunb . (Indongcho) have been utilized in folk remedies against inflammatory diseases. Recently, many agents that have used for inflammatory diseases are showing anticancer effects. Here, we have isolated polyphenols extracted from lyophilized Lonicera japonica Thunb (PELJ) and investigated the anticancer effects of PELJ on U937 cells. Here, we demonstrated that PELJ induced apoptosis by upregulation of DR4 and Fas, and further it is augmented by suppression of XIAP. In addition, The PELJ‐induced apoptosis is at least in part by blocking PI3K/Akt pathway. These findings suggest that PELJ may provide evidence of anticancer activities on U937 cells. Further study for detailed mechanism and the effects on animal models is warranted to determine whether PELJ provide more conclusive evidence that PELJ which may provide a beneficial effect for treating cancer.