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Possible therapeutic effect of carvacrol on asthmatic patients: A randomized, double blind, placebo‐controlled, Phase II clinical trial
Author(s) -
Alavinezhad Azam,
Khazdair Mohammad Reza,
Boskabady Mohammad Hossein
Publication year - 2018
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5967
Subject(s) - carvacrol , placebo , medicine , gastroenterology , pulmonary function testing , hematocrit , c reactive protein , asthma , respiratory system , anesthesia , immunology , biology , inflammation , pathology , alternative medicine , antimicrobial , microbiology and biotechnology
The relaxant effects of carvacrol, a phenolic monoterpene, on tracheal smooth muscle and its preventive effect on asthmatic animals were reported. The effect of carvacrol in asthmatic patients was examined in the placebo group (Group P, n = 11) receiving placebo and treatment group (Group C, n = 12), which received carvacrol capsule (1.2 mg/kg/day) for 2 months in a double‐blind manner. Pulmonary function tests, respiratory symptoms, hematological indices, and high‐sensitivity C‐reactive protein (hs‐CRP) were measured before, 1 and 2 months after starting treatment. At the end of treatment period, Pulmonary function tests values in Group C were significantly increased ( p < .05 to p < .001). Most respiratory symptoms were also significantly reduced in Group C at the end of 2‐month treatment ( p < .05 to p < .001). Total and differential white blood cell ( p < .05 to p < .001), as well as serum levels of hs‐CRP in Group C were also significantly reduced after 2‐month treatment with carvacrol ( p < .001). Mean corpuscular hemoglobin concentration and hematocrit were changed in Group C ( p < .05 and p < .01, respectively). However, in Group P, there was no significant changes in the evaluated parameters. Pulmonary function tests were increased but respiratory symptoms, inflammatory cells, and hs‐CRP were reduced in asthmatic patients who received carvacrol that indicates its therapeutic effect on asthma.