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Murraya paniculata (L.) (Orange Jasmine): Potential Nutraceuticals with Ameliorative Effect in Alloxan‐Induced Diabetic Rats
Author(s) -
Menezes Cicero Diego Almino,
Oliveira Garcia Francisca Adilfa,
Barros Viana Glauce Socorro,
Pinheiro Patricia Gonçalves,
Felipe Cícero Francisco Bezerra,
Albuquerque Thaís Rodrigues,
Moreira Alisson Cordeiro,
Santos Enaide Soares,
Cavalcante Maynara Rodrigues,
Garcia Tatiana Rodrigues,
Silva Thiago Fonseca,
Coutinho Henrique Douglas Melo,
Menezes Irwin Rose Alencar
Publication year - 2017
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5903
Subject(s) - glibenclamide , medicine , murraya , diabetes mellitus , metformin , traditional medicine , alloxan , pharmacology , lovastatin , endocrinology , cholesterol
Orange jasmine, Murraya paniculata (Rutaceae), is a plant from India widely used in folk medicine as antinociceptive, antiinflammatory, and antioxidant. Although oral hypoglycemic agents and insulin are the mainstays of treatment of diabetes mellitus (DM), there is a significant demand for new natural products to reduce the development of diabetic complications. Alloxan‐induced diabetic rats were treated for 60 days with a hydroalcoholic extract of M. paniculata (MPE), at doses of 100, 200, and 400 mg/kg. MPE decreased glycemia and also cholesterol and triglyceride levels, starting 1 week after treatments, as compared with the same group before treatments. Glucose values were reduced toward normality after 1 week of treatment. MPE hypoglycemic effects were potentiated by glibenclamide and metformin. MPE also decreased fructosamine and glycated hemoglobin values. MPE reduced diabetes‐induced morphological alterations of the kidney, pancreas, and liver. MPE acts similarly to glibenclamide and metformin, and its glucose‐lowering action is partly a consequence of ATP‐sensitive K + channel inhibition. MPE may be a potential therapeutic alternative for the treatment of diabetes and its complications. Copyright © 2017 John Wiley & Sons, Ltd.