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Bioactive Triterpenes from the Root of Salvia miltiorrhiza Bunge
Author(s) -
Tung Nguyen Huu,
Nakajima Kensuke,
Uto Takuhiro,
Hai Nguyen Thanh,
Long Dinh Doan,
Ohta Tomoe,
Oiso Shigeru,
Kariyazono Hiroko,
Shoyama Yukihiro
Publication year - 2017
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5877
Subject(s) - salvia miltiorrhiza , traditional medicine , terpene , pharmacognosy , phytotherapy , salvia , medicine , biology , botany , chemistry , biological activity , traditional chinese medicine , stereochemistry , in vitro , alternative medicine , biochemistry , pathology
Danshen ( Salvia miltiorrhiza ) is a well‐known medicinal herb in the oriental medicine. The current study on bioactive triterpenoid in the root of S. miltiorrhiza led to the isolation of a new highly hydroxylated ursane‐type triterpene, urs‐12‐ene‐2α,3β,7β,16α‐tetraol (1) and five known ones including 2β‐hydroxypomolic acid (2), maslinic acid (3), asiatic acid (4), ursolic acid (5), and oleanolic acid (6). Their structures were elucidated on the basis of extensive spectroscopic analyses and comparison with literature data. The antiproliferative testing against HL‐60 cells revealed that the new compound 1 and ursolic acid (5) showed weak and moderate activities with IC 50 values of 42.2 and 11.7 μM. In addition, compounds 1–3 showed inhibitory effect on ghrelin activity. Copyright © 2017 John Wiley & Sons, Ltd.