Premium
Standardized Passiflora incarnata L. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats
Author(s) -
Schunck Rebeca Vargas Antunes,
Macedo Isabel Cristina,
Laste Gabriela,
Souza Andressa,
Valle Marina Tuerlinckx Costa,
Salomón Janaína L.O.,
Nunes Ellen Almeida,
Campos Andreia Cristina Wildner,
Gnoatto Simone Cristina Baggio,
Bergold Ana Maria,
Konrath Eduardo L.,
Dallegrave Eliane,
Arbo Marcelo Dutra,
Torres Iraci L.S.,
Leal Mirna Bainy
Publication year - 2017
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5839
Subject(s) - nociception , anesthesia , alcohol , hippocampus , medicine , psychology , chemistry , biochemistry , receptor
Passiflora incarnata L. (Passifloraceae) has been traditionally used for treatment of anxiety, insomnia, drug addiction, mild infections, and pain. The aim of this study was to investigate the effect of a commercial extract of P. incarnata in the analgesia induced by alcohol withdrawal syndrome in rats. In addition, brain‐derived neurotrophic factor and interleukin‐10 levels were evaluated in prefrontal cortex, brainstem, and hippocampus. Male adult rats received by oral gavage: (1: water group) water for 19 days, 1 day interval and water (8 days); (2: P. incarnata group) water for 19 days, 1 day interval and P. incarnata 200 mg/kg (8 days); (3: alcohol withdrawal group) alcohol for 19 days, 1 day interval and water (8 days); and (4: P. incarnata in alcohol withdrawal) alcohol for 19 days, 1 day interval and P. incarnata 200 mg/kg (8 days). The tail‐flick and hot plate tests were used as nociceptive response measures. Confirming previous study of our group, it was showed that alcohol‐treated groups presented an increase in the nociceptive thresholds after alcohol withdrawal, which was reverted by P. incarnata , measured by the hot plate test. Besides, alcohol treatment increased brain‐derived neurotrophic factor and interleukin‐10 levels in prefrontal cortex, which was not reverted by P. incarnata . Considering these results, the P. incarnata treatment might be a potential therapy in the alcohol withdrawal syndrome. Copyright © 2017 John Wiley & Sons, Ltd.