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Baicalin Alleviates Nitroglycerin‐induced Migraine in Rats via the Trigeminovascular System
Author(s) -
Sun YuYao,
Zhang WenJun,
Dong CuiLan,
Zhang XiaoFan,
Ji Jun,
Wang Xue,
Wang Ling,
Hu WanLi,
Du WenJuan,
Cui ChengLong,
Zhang ChunFeng,
Li Fei,
Wang ChongZhi,
Yuan ChunSu
Publication year - 2017
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5811
Subject(s) - calcitonin gene related peptide , baicalin , migraine , medicine , calcitonin , periaqueductal gray , pharmacology , vasodilation , anesthesia , endocrinology , chemistry , neuropeptide , central nervous system , receptor , high performance liquid chromatography , chromatography , midbrain
Migraine is a common neurological disorder with a serious impact on quality of life. The aim of this study was to explore the effect of baicalin on nitroglycerin‐induced migraine rats. We carried out a behavioral research within 2 h post‐nitroglycerin injection, and blood samples were drawn for measurements of nitric oxide (NO), calcitonin gene‐related peptide, and endothelin (ET) levels. Immunohistochemistry was adopted to detect the activation of C‐fos immunoreactive neurons in periaqueductal gray. The number, area size, and integrated optical density of C‐fos positive cells were measured using Image‐Pro Plus. As a result, baicalin administration (0.22 mm/kg) alleviated pain responses of migraine rats. It profoundly decreased NO and calcitonin gene‐related peptide levels, increased ET levels, and rebuilt the NO/ET balance in migraine rats. Besides, baicalin pretreatment significantly reduced the number, the stained area size, and integrated optical density value of C‐fos positive cells. In brief, this paper supports the possibility of baicalin as a potential migraine pharmacotherapy. Copyright © 2017 John Wiley & Sons, Ltd.