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Efficacy and Safety of Cissus quadrangularis L. in Clinical Use: A Systematic Review and Meta‐analysis of Randomized Controlled Trials
Author(s) -
Sawangjit Ratree,
Puttarak Panupong,
Saokaew Surasak,
Chaiyakunapruk Nathorn
Publication year - 2017
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5783
Subject(s) - medicine , placebo , meta analysis , adverse effect , traditional medicine , randomized controlled trial , triglyceride , cholesterol , alternative medicine , pathology
Cissus quadrangularis L. (Cissus) is a medicinal plant commonly used for centuries for various conditions, but lacks critical appraisal of its clinical effects. This study aimed to determine the efficacy and safety of Cissus in all conditions. Publications from 12 electronic databases were searched from inception through November 2016. A total of nine studies with 1108 patients were included. Each outcome was pooled using a random effects model. Effects of Cissus on hemorrhoid symptoms were not different from any comparators but had significant effects on bone pain. Effects of Cissus combination products on body weight reduction, low‐density lipoprotein, triglyceride, total cholesterol, and fasting blood sugar were superior to placebo, with weighted mean difference of −5.19 kg (−8.82, −1.55), −14.43 mg/dl (−20.06, −8.80), −37.50 mg/dl (−48.71, −26.29), −50.50 mg/dl (−70.97, −30.04), and −10.39 mg/dl (−14.60, −6.18), respectively. No serious adverse effects were reported. Quality of evidence based on Grades of Recommendations Assessment Development and Evaluation (GRADE) indicated low (bone fractures) to high quality (hemorrhoids, body weight reduction).In conclusion, Cissus had benefit for bone fractures, but not for hemorrhoids. For obesity/overweight, only combination products are pooled and show benefit. However, high‐quality studies remain needed. Copyright © 2017 John Wiley & Sons, Ltd.