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Effects of Curcumin on Serum Vitamin E Concentrations in Individuals with Metabolic Syndrome
Author(s) -
Mohammadi Akram,
Sadeghnia Hamid Reza,
SaberiKarimian Maryam,
Safarian Hamideh,
Ferns Gordon A.,
GhayourMobarhan Majid,
Sahebkar Amirhossein
Publication year - 2017
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5779
Subject(s) - curcumin , medicine , vitamin e , triglyceride , vitamin , placebo , antioxidant , endocrinology , cholesterol , high density lipoprotein , metabolic syndrome , diabetes mellitus , chemistry , pharmacology , biochemistry , alternative medicine , pathology
Vitamin E is an important lipid‐soluble antioxidant. The aim of the present study was to investigate the effect of curcumin on serum vitamin E levels in subjects with metabolic syndrome (MetS). A total of 120 subjects aged 18–65 years old with MetS were recruited in this study according to the International Diabetic Federation Criteria. Included subjects were randomized into three groups: subjects receiving lecithinized curcumin (1 g/day equivalent to 200‐mg pure curcumin per day) for a period of 6 weeks ) n = 40), patients receiving unformulated curcumin (1 g/day) for a period of 6 weeks ) n = 40) and a control group receiving placebo for the same period ( n = 40). Vitamin E was determined in all patients before and after the intervention using high‐performance liquid chromatography method. Results showed that curcumin has no improving effect on serum levels of vitamin E ( p > 0.05). There were significant differences between pre‐trial and post‐trial levels of vitamin E/low‐density lipoprotein cholesterol ratio ( p < 0.05), vitamin E/high‐density lipoprotein cholesterol ratio ( p < 0.05), vitamin E/total cholesterol ratio ( p < 0.01) and vitamin E/triglyceride ratio ( p < 0.05) between the three groups of the study. Results of the present study did not suggest any improving effect of curcumin supplementation on serum vitamin E concentrations in subjects with MetS. Copyright © 2017 John Wiley & Sons, Ltd.