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Triterpenoids‐Enriched Extract from the Aerial Parts of Salvia miltiorrhiza Regulates Macrophage Polarization and Ameliorates Insulin Resistance in High‐Fat Fed Mice
Author(s) -
Leng Jing,
Chen MeiHong,
Zhou ZhiHui,
Lu YaWen,
Wen XiaoDong,
Yang Jie
Publication year - 2017
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5736
Subject(s) - insulin resistance , macrophage polarization , salvia miltiorrhiza , endocrinology , ampk , medicine , adipose tissue , insulin receptor , hyperlipidemia , m2 macrophage , protein kinase b , insulin , pi3k/akt/mtor pathway , adipose tissue macrophages , inflammation , biology , macrophage , kinase , signal transduction , microbiology and biotechnology , protein kinase a , diabetes mellitus , biochemistry , in vitro , pathology , alternative medicine , traditional chinese medicine
Adipose tissue inflammation and macrophage polarization are tightly associated with the development of obesity‐associated insulin resistance. Our previous studies have demonstrated the triterpenoids‐enriched extract from the aerial parts of Salvia miltiorrhiza (TTE) could significantly improve atherosclerosis in LDLR −/− mice. However, its molecular mechanisms of TTE ameliorating insulin resistance remain unclear. In the present study, obesity model with insulin resistance induced by feeding high‐fat diet (HFD) was established. Dietary TTE attenuated hyperlipidemia, improved glucose intolerance in mice and mediated the activation of IRS‐1/PI3K/Akt insulin signaling pathway. Meanwhile, dietary TTE also attenuated macrophage infiltrations into adipose tissue and modified the phenotype ratio of M1/M2 macrophages. Furthermore, our results showed that TTE regulated the polarization of macrophages partly via adenosine monophosphate‐activated kinase (AMPK). Taken together, these findings suggested that TTE has a potential clinical utility in improving insulin resistance. Its mechanisms might be contributed to its beneficial effects on macrophage polarization via AMPK. Copyright © 2016 John Wiley & Sons, Ltd.