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The Chemistry and Biological Activities of Mimosine: A Review
Author(s) -
Nguyen Binh Cao Quan,
Tawata Shinkichi
Publication year - 2016
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5636
Subject(s) - mimosine , biology , biochemistry , amino acid , chemistry , botany , leucaena leucocephala
Mimosine [ β ‐[ N ‐(3‐hydroxy‐4‐oxypyridyl)]‐ α ‐aminopropionic acid] is a non‐protein amino acid found in the members of Mimosoideae family. There are a considerable number of reports available on the chemistry, methods for estimation, biosynthesis, regulation, and degradation of this secondary metabolite. On the other hand, over the past years of active research, mimosine has been found to have various biological activities such as anti‐cancer, antiinflammation, anti‐fibrosis, anti‐influenza, anti‐virus, herbicidal and insecticidal activities, and others. Mimosine is a leading compound of interest for use in the development of RAC/CDC42‐activated kinase 1 (PAK1)‐specific inhibitors for the treatment of various diseases/disorders, because PAK1 is not essential for the growth of normal cells. Interestingly, the new roles of mimosine in malignant glioma treatment, regenerative dentistry, and phytoremediation are being emerged. These identified properties indicate an exciting future for this amino acid. The present review is focused on the chemistry and recognized biological activities of mimosine in an attempt to draw a link between these two characteristics. Copyright © 2016 John Wiley & Sons, Ltd.