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Effect of Subgingivally Delivered 10% Emblica officinalis Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis – A Randomized Placebo‐controlled Clinical Trial
Author(s) -
Grover Shilpa,
Tewari Shikha,
Sharma Rajinder K,
Singh Gajendra,
Yadav Aparna,
Naula Satish C
Publication year - 2016
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5600
Subject(s) - scaling and root planing , emblica officinalis , medicine , chronic periodontitis , dentistry , officinalis , phytotherapy , periodontitis , placebo , randomized controlled trial , traditional medicine , alternative medicine , pathology
Emblica officinalis fruit possesses varied medicinal properties including cytoprotective antimicrobial, antioxidant, antiresorptive and antiinflammatory activity. The present study aimed to investigate the effect of subgingival application of indigenously prepared E. officinalis (Amla) sustained‐release gel adjunctive to scaling and root planing (SRP) on chronic periodontitis. Forty‐six patients (528 sites) were randomly assigned to control group (23;264): SRP +placebo gel and test group (23;264): SRP + 10% E. officinalis gel application. Periodontal parameters: plaque index, gingival index, probing pocket depth (PPD), clinical attachment level (CAL) and modified sulcus bleeding index (mSBI) were assessed at baseline, 2 and 3‐month post‐therapy. Forty patients (470 sites) completed the trial. When test and control sites were compared, significantly more reduction in mean PPD, mSBI, number of sites with PPD = 5–6 mm, PPD ≥ 7 mm, CAL ≥ 6 mm and greater CAL gain were achieved in test sites at 2‐ and 3‐month post‐therapy ( p < 0.05). Locally delivered 10% E. officinalis sustained‐release gel used as an adjunct to SRP may be more effective in reducing inflammation and periodontal destruction in patients with chronic periodontitis when compared with SRP alone. Copyright © 2016 John Wiley & Sons, Ltd.