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Polygonum aviculare L. and its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β‐catenin pathway and induce cutaneous wound healing
Author(s) -
Seo Seol Hwa,
Lee SoungHoon,
Cha PuHyeon,
Kim MiYeon,
Min Do Sik,
Choi KangYell
Publication year - 2016
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5593
Subject(s) - quercitrin , hacat , wnt signaling pathway , chemistry , caffeic acid , traditional medicine , rutin , biology , biochemistry , antioxidant , signal transduction , medicine , in vitro
Polygonum aviculare L. is a member of the Polygonaceae family of plants, which has been known for its antioxidant and anti‐obesity effects. However, the wound healing function of P . aviculare extract has not been assessed. In this study, we identified a novel property of P . aviculare extract as a Wnt/β‐catenin pathway activator based on a screen of 350 plant extracts using HEK293‐TOP cells retaining the Wnt/β‐catenin signaling reporter gene. P . aviculare extract accelerated the migration of HaCaT keratinocytes without showing significant cytotoxicity. Moreover, P . aviculare extract efficiently re‐epithelized wounds generated on mice. Additionally, ingredients of P . aviculare extract, such as quercitrin hydrate, caffeic acid, and rutin, also accelerated the motility of HaCaT keratinocytes with the activation of Wnt/β‐catenin signaling. Therefore, based on our findings, P . aviculare extract and its active ingredients could be potential therapeutic agents for wound healing. Copyright © 2016 John Wiley & Sons, Ltd.