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Cardioprotective Efficacy of Red Wine Extract of Onion in Healthy Hypercholesterolemic Subjects
Author(s) -
Chiu HuiFang,
Shen YouCheng,
Huang TingYun,
Venkatakrishnan Kamesh,
Wang ChinKun
Publication year - 2016
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5537
Subject(s) - wine , traditional medicine , pharmacognosy , medicine , food science , biology , biochemistry , biological activity , in vitro
The objective of this study was to evaluate the efficacy of the red wine extract of onion (RO) and red wine (RW) on alleviating the risk factors of cardiovascular disease. During in vitro studies, various antioxidant activities [trolox equivalent antioxidant capacity (TEAC), DPPH, and H 2 O 2 scavenging ability] of RO and RW group were evaluated. Both RO and RW showed the maximum antioxidant capacity. During in vivo studies, 23 healthy hypercholesterolemic volunteers were randomly selected and assigned into two groups, who drunk 250 mL of RO ( n = 11) or RW ( n = 10) for 10 weeks. No significant changes were observed in anthropometric parameters (body weight, height, body mass, and BMI) in each group. Both RW and RO extracts elevated ( p < 0.05) antioxidant activity and thereby prolonging the lag time of low‐density lipoprotein oxidation. However, RO extract intake substantially suppressed ( p < 0.05) the total cholesterol and low‐density lipoprotein cholesterol levels when equivalence with RW thus, indicating its additional hypocholesterolemic effect. The inflammatory markers such as factor VII were also positively modulated by RO extract. Results indicated that RO extract consumption rendered better cardio protective effect than RW by altering cholesterol, improving antioxidation and suppressing inflammatory marker levels and thereby, attenuating the cardiovascular disease incidence. Copyright © 2015 John Wiley & Sons, Ltd.