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Colon Cancer Chemoprevention by Sage Tea Drinking: Decreased DNA Damage and Cell Proliferation
Author(s) -
Pedro Dalila F. N.,
Ramos Alice A.,
Lima Cristovao F.,
Baltazar Fatima,
PereiraWilson Cristina
Publication year - 2016
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5531
Subject(s) - azoxymethane , salvia officinalis , sage , colorectal cancer , carcinogenesis , in vivo , cell growth , aberrant crypt foci , cancer , cancer research , dna damage , phytotherapy , dna repair , biology , pharmacology , medicine , traditional medicine , biochemistry , officinalis , pathology , dna , genetics , colonic disease , physics , alternative medicine , nuclear physics
Salvia officinalis and some of its isolated compounds have been found to be preventive of DNA damage and increased proliferation in vitro in colon cells. In the present study, we used the azoxymethane model to test effects of S. officinalis on colon cancer prevention in vivo . The results showed that sage treatment reduced the number of ACF formed only if administered before azoxymethane injection, demonstrating that sage tea drinking has a chemopreventive effect on colorectal cancer. A decrease in the proliferation marker Ki67 and in H 2 O 2 ‐induced and azoxymethane‐induced DNA damage to colonocytes and lymphocytes were found with sage treatment. This confirms in vivo the chemopreventive effects of S. officinalis . Taken together, our results show that sage treatment prevented initiation phases of colon carcinogenesis, an effect due, at least in part, to DNA protection, and reduced proliferation rates of colon epithelial cell that prevent mutations and their fixation through cell replication. These chemopreventive effects of S. officinalis on colon cancer add to the many health benefits attributed to sage and encourage its consumption. Copyright © 2015 John Wiley & Sons, Ltd.