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Camphor Induces Proliferative and Anti‐senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV‐Induced Wrinkle Formation in Mouse Skin
Author(s) -
Tran Thao Anh,
Ho Manh Tin,
Song Yeon Woo,
Cho Moonjae,
Cho Somi Kim
Publication year - 2015
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5484
Subject(s) - camphor , elastin , chemistry , human skin , pharmacology , biology , medicine , pathology , organic chemistry , genetics
Camphor ((1 R )‐1,7,7‐trimethylbicyclo[2.2.1]heptan‐2‐one), a bicyclic monoterpene, is one of the major constituents of essential oils from various herbs such as rosemary, lavender, and sage. In this study, we investigated the beneficial effects of camphor as a botanical ingredient in cosmetics. Camphor induced the proliferation of human primary dermal fibroblasts in a dose‐dependent manner via the PI3K/AKT and ERK signaling pathways. Camphor attenuated the elevation of senescence associated with β‐galactosidase (SA‐β‐gal) activity. Elastase activity decreased, while the total amount of collagen increased, in a dose‐ and time‐dependent manner in human primary dermal fibroblasts treated with camphor. Camphor induced the expression of collagen IA, collagen IIIA, collagen IVA, and elastin in human primary dermal fibroblasts. In addition, posttreatment with 26 and 52 mM camphor for 2 weeks led to a significant reduction in the expression of MMP1 but increases in the expression of collagen IA, IIIA, and elastin in mouse skin exposed to UV for 4 weeks. These posttreatments also reduced the depths of the epidermis and subcutaneous fat layer in UV‐exposed mouse skin. Taken together, these findings suggest camphor to be a potent wound healing and antiwrinkle agent with considerable potential for use in cosmeceuticals. Copyright © 2015 John Wiley & Sons, Ltd.