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Effect of Serenoa Repens on Oxidative Stress, Inflammatory and Growth Factors in Obese Wistar Rats with Benign Prostatic Hyperplasia
Author(s) -
III ColadoVelázquez Juventino,
MaillouxSalinas Patrick,
MedinaContreras JML,
CruzRobles David,
Bravo Guadalupe
Publication year - 2015
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5406
Subject(s) - malondialdehyde , hyperplasia , oxidative stress , endocrinology , medicine , vascular endothelial growth factor , superoxide dismutase , glutathione , chemistry , biochemistry , vegf receptors , enzyme
Serenoa repens has been widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms; however, most of the studies have been conducted in individuals with normal weight and not obese. In this study, the effects of a lipidic extract of S. repens , in markers of oxidative stress, inflammation, and growth factors, in obese rats with testosterone‐induced prostatic hyperplasia, were investigated. Total nitrites, malondialdehyde, total glutathione, superoxide dismutase (SOD), and catalase activity were measured; in addition, assays for inflammatory cytokines TNF‐ α , IL‐1β, IL‐6 and the growth factors basic fibroblast growth factor (FGFb) and vascular endothelial growth factor (VEGF) were performed. The obese rats had a higher prostate weight compared with controls. S. repens significantly decreased prostate weight, total nitrites, and malondialdehyde; improved total glutathione, SOD, and catalase activity; and significantly reduced inflammatory (TNF‐α, IL‐1β and IL‐6) and growth factors (VEGF and FGFb). S. repens showed high antioxidant and antiinflammatory activity in obese rats, suggesting that their use could be beneficial in the treatment of benign prostatic hyperplasia. Copyright © 2015 John Wiley & Sons, Ltd.