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Consumption of Argan Oil Improves Anti‐Oxidant and Lipid Status in Hemodialysis Patients
Author(s) -
Eljaoudi Rachid,
Elkabbaj Driss,
Bahadi Abdelali,
Ibrahimi Azeddine,
Benyahia Mohammed,
Errasfa Mourad
Publication year - 2015
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5405
Subject(s) - hemodialysis , malondialdehyde , oxidative stress , antioxidant , triglyceride , vitamin e , medicine , vitamin c , lipid profile , cholesterol , lipoprotein , endocrinology , food science , biochemistry , chemistry
Objective: Virgin Argan oil (VAO) is of interest in oxidative stress and lipid profile because of its fat composition and antioxidant compounds. We investigated the effect of VAO consumption on lipid profile and antioxidant status in hemodialysis patients after a 4‐week period of consumption. Methods: In a crossover, controlled trial, 37 patients (18 men, 19 women) with end‐stage renal disease on maintenance hemodialysis, were randomly assigned to a 4‐week VAO diet. Fasting plasma lipids, vitamin E and oxidized LDL (ox‐LDL) were analyzed. Malondialdehyde (MDA) was determined before and after hemodialysis session. Results: There was no significant change in serum total cholesterol and ox‐LDL. However, VAO consumption decreased the levels of triglyceride (p = 0.03), total cholesterol (p = 0.02) and low‐density lipoprotein (p = 0.03) and increased the levels of high‐density lipoprotein (p = 0.01). Plasma vitamin E contents significantly increased from baseline only in VAO‐group (p < 0.001). Hemodialysis session increased MDA levels, but the increase in VAO group was less than in control group. Conclusion: VAO consumption improved lipid profile and oxidative stress status in hemodialysis patients. Copyright © 2015 John Wiley & Sons, Ltd.