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Blood Glucose‐lowering Effect of T. procumbens L.: A Pilot Clinical Study in Individuals with Type 2 Diabetes
Author(s) -
Desai Gauri S.,
Desai Shirish V.,
Gavaskar Rajendra S.,
Mulabagal Vanisree,
Wu Yonnie,
Mathews Suresh T.
Publication year - 2015
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5394
Subject(s) - type 2 diabetes , diabetes mellitus , antioxidant , medicine , traditional medicine , polyphenol , high performance liquid chromatography , pharmacology , chemistry , endocrinology , biochemistry , chromatography
Traditional knowledge, in vitro studies, and studies using animal models suggest that Tridax procumbens L. exhibits blood glucose‐lowering properties and antiinflammatory effects. In this study, we evaluated the blood glucose‐lowering effect of T. procumbens supplementation in individuals with type 2 diabetes. An extract ( asava ) of T. procumbens L. was prepared following Ayurveda guidelines. Chemical and microbial analyses indicated presence of phenolics, flavonoids, and carotenoids, and absence of microbial contamination, aflatoxins, heavy metals, and pesticide residues. A chemical fingerprint of T. procumbens L. asava , developed using Ultra high pressure liquid chromatography/electron spray ionization‐mass spectrometry (UPLC/ESI‐MS) in negative mode, suggest the presence of several compounds including polyphenols. T. procumbens asava demonstrated strong total antioxidant capacity, Fe 3+ reducing potential, Fe 2+ chelation, H 2 O 2 scavenging activity, and inhibition of lipid peroxidation. We recruited 20 type 2 diabetic individuals from Kolhapur, India. Participants received 15 mL of T. procumbens asava , twice daily, for 4 weeks, while continuing their prescribed antidiabetic medications. Fasting blood glucose decreased by 11% in men ( p < 0.01) and 20% in women ( p < 0.05), and post‐prandial blood glucose concentrations were lowered by 26% in men ( p < 0.001) and 29% in women ( p < 0.001) following 4 weeks of asava supplementation. No adverse events or side effects were reported. This is the first clinical study demonstrating a significant blood glucose‐lowering effect of T. procumbens asava in type 2 diabetes. Copyright © 2015 John Wiley & Sons, Ltd.